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Human Tumor necrosis factor (a.a.77-233)

TNFA Swiss Prot#

P01375

TNFA Protein names

Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Cleaved into: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

TNFA Gene names

TNF TNFA TNFSF2

Organism

Human

TNFA Entry name

TNFA_HUMAN

TNFA Codon optimized cDNA(gene) Clone

TNFA Cat #

RPA0280

Tag

TNFA contains A 6x histidine tag

TNFA Formulation

Liquid

TNFA Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

TNFA Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant TNFA Protein

TNFA Cat #

PA0280

TNFA Source

recombinant

TNFA Applications

Western Blot, SDS-Page or may be used for other applications determined by user

TNFA Purity

>90%, as determined by SDS-PAGE under reducing conditions

TNFA Activity

N/A

Tag

TNFA Contains A 6x histidine tag

TNFA Formulation

Liquid

TNFA Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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TNFA family

Tumor necrosis factor family

TNFA Subcellular locations

Cell membrane; Single-pass type II membrane protein. Secreted.

TNFA FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.

TNFA Sequence

DDBJ

EMBL

GenBank

TNFA 3D structure

ModBase

TNFA interaction

STRING

TNFA Proteomic

PRIDE

TNFA Genome annotation

Ensembl

GeneID

KEGG

UCSC

TNFA Organism specific

CTD

MGI

TNFA Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

TNFA Gene expression

Bgee

ArrayExpress

Genevestigator

TNFA Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY