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Human Tumor necrosis factor receptor superfamily 10B (a.a.52-183)

DR5 Swiss Prot#

O14763

DR5 Protein names

Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262)

DR5 Gene names

TNFRSF10B DR5 KILLER TRAILR2 TRICK2 ZTNFR9 UNQ160/PRO186

Organism

Human

DR5 Entry name

TR10B_HUMAN

DR5 Codon optimized cDNA(gene) Clone

DR5 Cat #

RPA0258

Tag

DR5 contains A 6x histidine tag

DR5 Formulation

Liquid

DR5 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

DR5 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant DR5 Protein

DR5 Cat #

PA0258

DR5 Source

recombinant

DR5 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

DR5 Purity

>90%, as determined by SDS-PAGE under reducing conditions

DR5 Activity

N/A

Tag

DR5 Contains A 6x histidine tag

DR5 Formulation

Liquid

DR5 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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DR5 family

-

DR5 Subcellular locations

Membrane; Single-pass type I membrane protein.

DR5 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.

DR5 Sequence

DDBJ

EMBL

GenBank

DR5 3D structure

ModBase

DR5 interaction

STRING

DR5 Proteomic

PRIDE

DR5 Genome annotation

Ensembl

GeneID

KEGG

UCSC

DR5 Organism specific

CTD

MGI

DR5 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

DR5 Gene expression

Bgee

ArrayExpress

Genevestigator

DR5 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY