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Human Tumor necrosis factor receptor superfamily 11B (a.a.22-194)

OCIF Swiss Prot#

O00300

OCIF Protein names

Tumor necrosis factor receptor superfamily member 11B (Osteoprotegerin) (Osteoclastogenesis inhibitory factor)

OCIF Gene names

TNFRSF11B OCIF OPG

Organism

Human

OCIF Entry name

TR11B_HUMAN

OCIF Codon optimized cDNA(gene) Clone

OCIF Cat #

RPA0254

Tag

OCIF contains A 6x histidine tag

OCIF Formulation

Liquid

OCIF Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

OCIF Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant OCIF Protein

OCIF Cat #

PA0254

OCIF Source

recombinant

OCIF Applications

Western Blot, SDS-Page or may be used for other applications determined by user

OCIF Purity

>90%, as determined by SDS-PAGE under reducing conditions

OCIF Activity

N/A

Tag

OCIF Contains A 6x histidine tag

OCIF Formulation

Liquid

OCIF Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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OCIF family

-

OCIF Subcellular locations

Secreted.

OCIF FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.

OCIF Sequence

DDBJ

EMBL

GenBank

OCIF 3D structure

ModBase

OCIF interaction

STRING

OCIF Proteomic

PRIDE

OCIF Genome annotation

Ensembl

GeneID

KEGG

UCSC

OCIF Organism specific

CTD

MGI

OCIF Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

OCIF Gene expression

Bgee

ArrayExpress

Genevestigator

OCIF Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY