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Human Tumor necrosis factor receptor superfamily 10A (a.a.25-239)

APO2 Swiss Prot#

O00220

APO2 Protein names

Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261)

APO2 Gene names

TNFRSF10A APO2 DR4 TRAILR1

Organism

Human

APO2 Entry name

TR10A_HUMAN

APO2 Codon optimized cDNA(gene) Clone

APO2 Cat #

RPA0253

Tag

APO2 contains A 6x histidine tag

APO2 Formulation

Liquid

APO2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

APO2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant APO2 Protein

APO2 Cat #

PA0253

APO2 Source

recombinant

APO2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

APO2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

APO2 Activity

N/A

Tag

APO2 Contains A 6x histidine tag

APO2 Formulation

Liquid

APO2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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APO2 family

-

APO2 Subcellular locations

Membrane; Single-pass type I membrane protein.

APO2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.

APO2 Sequence

DDBJ

EMBL

GenBank

APO2 3D structure

ModBase

APO2 interaction

STRING

APO2 Proteomic

PRIDE

APO2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

APO2 Organism specific

CTD

MGI

APO2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

APO2 Gene expression

Bgee

ArrayExpress

Genevestigator

APO2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY