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Human V-set domain-containing T-cell activation inhibitor 1 (aa 25-282)

B7H4 Swiss Prot#

Q7Z7D3

B7H4 Protein names

V-set domain-containing T-cell activation inhibitor 1 (Immune costimulatory protein B7-H4) (B7h.5) (T-cell costimulatory molecule B7x) (Protein B7S1)

B7H4 Gene names

VTCN1 (B7H4) (UNQ659/PRO1291)

Organism

Human

B7H4 Entry name

VTCN1_HUMAN

B7H4 Codon optimized cDNA(gene) Clone

B7H4 Cat #

RPA0250

Tag

B7H4 contains A 6x histidine tag

B7H4 Formulation

Liquid

B7H4 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

B7H4 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant B7H4 Protein

B7H4 Cat #

PA0250

B7H4 Source

recombinant

B7H4 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

B7H4 Purity

>90%, as determined by SDS-PAGE under reducing conditions

B7H4 Activity

N/A

Tag

B7H4 Contains A 6x histidine tag

B7H4 Formulation

Liquid

B7H4 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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B7H4 family

Immunoglobulin superfamily, BTN/MOG family

B7H4 Subcellular locations

Cell membrane; Single-pass type I membrane protein.

B7H4 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.

B7H4 Sequence

DDBJ

EMBL

GenBank

B7H4 3D structure

ModBase

B7H4 interaction

STRING

B7H4 Proteomic

PRIDE

B7H4 Genome annotation

Ensembl

GeneID

KEGG

UCSC

B7H4 Organism specific

CTD

MGI

B7H4 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

B7H4 Gene expression

Bgee

ArrayExpress

Genevestigator

B7H4 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY