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Human Tumor necrosis factor ligand superfamily 12 (aa 1-249)
APO3L Swiss Prot#
O43508
APO3L Protein names
Tumor necrosis factor ligand superfamily member 12 (TNF-related weak inducer of apoptosis) (TWEAK) (APO3 ligand) [Cleaved into: Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form]
APO3L Gene names
TNFSF12 (APO3L) (DR3LG) (UNQ181/PRO207)
Organism
Human
APO3L Entry name
TNF12_HUMAN
APO3L Codon optimized cDNA(gene) Clone
APO3L Cat #
RPA0242
Tag
APO3L contains A 6x histidine tag
APO3L Formulation
Liquid
APO3L Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
APO3L Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant APO3L Protein
APO3L Cat #
PA0242
APO3L Source
recombinant
APO3L Applications
Western Blot, SDS-Page or may be used for other applications determined by user
APO3L Purity
>90%, as determined by SDS-PAGE under reducing conditions
APO3L Activity
N/A
Tag
APO3L Contains A 6x histidine tag
APO3L Formulation
Liquid
APO3L Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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APO3L family
Tumor necrosis factor family
APO3L Subcellular locations
Cell membrane; Single-pass type II membrane protein. Secreted.
APO3L FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines.
APO3L Sequence
DDBJ EMBL GenBank
APO3L 3D structure
ModBase
APO3L interaction
STRING
APO3L Proteomic
PRIDE
APO3L Genome annotation
Ensembl GeneID KEGG UCSC
APO3L Organism specific
CTD MGI
APO3L Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
APO3L Gene expression
Bgee ArrayExpress Genevestigator
APO3L Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY