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Human Toll interleukin-1 1-receptor domain-containing (aa 1-221)

MAL Swiss Prot#

P58753

MAL Protein names

Toll/interleukin-1 1-receptor domain-containing adapter protein (TIR domain-containing adapter protein) (MyD88 adapter-like protein) (Adaptor protein Wyatt)

MAL Gene names

TIRAP (MAL)

Organism

Human

MAL Entry name

TIRAP_HUMAN

MAL Codon optimized cDNA(gene) Clone

MAL Cat #

RPA0240

Tag

MAL contains A 6x histidine tag

MAL Formulation

Liquid

MAL Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

MAL Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant MAL Protein

MAL Cat #

PA0240

MAL Source

recombinant

MAL Applications

Western Blot, SDS-Page or may be used for other applications determined by user

MAL Purity

>90%, as determined by SDS-PAGE under reducing conditions

MAL Activity

N/A

Tag

MAL Contains A 6x histidine tag

MAL Formulation

Liquid

MAL Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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MAL family

-

MAL Subcellular locations

Cytoplasm.

MAL FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.

MAL Sequence

DDBJ

EMBL

GenBank

MAL 3D structure

ModBase

MAL interaction

STRING

MAL Proteomic

PRIDE

MAL Genome annotation

Ensembl

GeneID

KEGG

UCSC

MAL Organism specific

CTD

MGI

MAL Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

MAL Gene expression

Bgee

ArrayExpress

Genevestigator

MAL Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY