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Human TNF 1-receptor-associated factor 6 (aa 1-522)

RNF85 Swiss Prot#

Q9Y4K3

RNF85 Protein names

TNF 1-receptor-associated factor 6 (Interleukin-1 signal transducer) (RING finger protein 85)

RNF85 Gene names

TRAF6 (RNF85)

Organism

Human

RNF85 Entry name

TRAF6_HUMAN

RNF85 Codon optimized cDNA(gene) Clone

RNF85 Cat #

RPA0236

Tag

RNF85 contains A 6x histidine tag

RNF85 Formulation

Liquid

RNF85 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

RNF85 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant RNF85 Protein

RNF85 Cat #

PA0236

RNF85 Source

recombinant

RNF85 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

RNF85 Purity

>90%, as determined by SDS-PAGE under reducing conditions

RNF85 Activity

N/A

Tag

RNF85 Contains A 6x histidine tag

RNF85 Formulation

Liquid

RNF85 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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RNF85 family

TNF receptor-associated factor family, A subfamily

RNF85 Subcellular locations

Cytoplasm. Cytoplasm > cell cortex. Nucleus.

RNF85 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor.

RNF85 Sequence

DDBJ

EMBL

GenBank

RNF85 3D structure

ModBase

RNF85 interaction

STRING

RNF85 Proteomic

PRIDE

RNF85 Genome annotation

Ensembl

GeneID

KEGG

UCSC

RNF85 Organism specific

CTD

MGI

RNF85 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

RNF85 Gene expression

Bgee

ArrayExpress

Genevestigator

RNF85 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY