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Human Suppressor of cytokine signaling 5 (aa 1-536)
CIS6 Swiss Prot#
O75159
CIS6 Protein names
Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2-containing protein 5) (Cytokine-inducible SH2 protein 6) (CIS-6)
CIS6 Gene names
SOCS5 (CIS6) (CISH5) (CISH6) (KIAA0671)
Organism
Human
CIS6 Entry name
SOCS5_HUMAN
CIS6 Codon optimized cDNA(gene) Clone
CIS6 Cat #
RPA0222
Tag
CIS6 contains A 6x histidine tag
CIS6 Formulation
Liquid
CIS6 Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
CIS6 Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant CIS6 Protein
CIS6 Cat #
PA0222
CIS6 Source
recombinant
CIS6 Applications
Western Blot, SDS-Page or may be used for other applications determined by user
CIS6 Purity
>90%, as determined by SDS-PAGE under reducing conditions
CIS6 Activity
N/A
Tag
CIS6 Contains A 6x histidine tag
CIS6 Formulation
Liquid
CIS6 Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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CIS6 family
-
CIS6 Subcellular locations
-
CIS6 FUNCTION According to UniProtKB Swiss Prot
FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS5 is involved in regulating T-helper cell differentiation by inhibition of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling (By similarity). May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
CIS6 Sequence
DDBJ EMBL GenBank
CIS6 3D structure
ModBase
CIS6 interaction
STRING
CIS6 Proteomic
PRIDE
CIS6 Genome annotation
Ensembl GeneID KEGG UCSC
CIS6 Organism specific
CTD MGI
CIS6 Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
CIS6 Gene expression
Bgee ArrayExpress Genevestigator
CIS6 Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY