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Human Suppressor of cytokine signaling 3 (aa 1-225)

CIS3 Swiss Prot#

O14543

CIS3 Protein names

Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)

CIS3 Gene names

SOCS3 (CIS3) (SSI3)

Organism

Human

CIS3 Entry name

SOCS3_HUMAN

CIS3 Codon optimized cDNA(gene) Clone

CIS3 Cat #

RPA0221

Tag

CIS3 contains A 6x histidine tag

CIS3 Formulation

Liquid

CIS3 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CIS3 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CIS3 Protein

CIS3 Cat #

PA0221

CIS3 Source

recombinant

CIS3 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CIS3 Purity

>90%, as determined by SDS-PAGE under reducing conditions

CIS3 Activity

N/A

Tag

CIS3 Contains A 6x histidine tag

CIS3 Formulation

Liquid

CIS3 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CIS3 family

-

CIS3 Subcellular locations

-

CIS3 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).

CIS3 Sequence

DDBJ

EMBL

GenBank

CIS3 3D structure

ModBase

CIS3 interaction

STRING

CIS3 Proteomic

PRIDE

CIS3 Genome annotation

Ensembl

GeneID

KEGG

UCSC

CIS3 Organism specific

CTD

MGI

CIS3 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CIS3 Gene expression

Bgee

ArrayExpress

Genevestigator

CIS3 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY