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Human Suppressor of cytokine signaling 2 (aa 1-198)

CIS2 Swiss Prot#

O14508

CIS2 Protein names

Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2)

CIS2 Gene names

SOCS2 (CIS2) (SSI2) (STATI2)

Organism

Human

CIS2 Entry name

SOCS2_HUMAN

CIS2 Codon optimized cDNA(gene) Clone

CIS2 Cat #

RPA0220

Tag

CIS2 contains A 6x histidine tag

CIS2 Formulation

Liquid

CIS2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CIS2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CIS2 Protein

CIS2 Cat #

PA0220

CIS2 Source

recombinant

CIS2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CIS2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

CIS2 Activity

N/A

Tag

CIS2 Contains A 6x histidine tag

CIS2 Formulation

Liquid

CIS2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CIS2 family

-

CIS2 Subcellular locations

-

CIS2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

CIS2 Sequence

DDBJ

EMBL

GenBank

CIS2 3D structure

ModBase

CIS2 interaction

STRING

CIS2 Proteomic

PRIDE

CIS2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

CIS2 Organism specific

CTD

MGI

CIS2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CIS2 Gene expression

Bgee

ArrayExpress

Genevestigator

CIS2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY