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| Human Pleckstrin homology domain-containing family O 1 (aa 1-409) |
| CKIP1 Swiss Prot# | | Q53GL0 |
| CKIP1 Protein names | | Pleckstrin homology domain-containing family O member 1 (Casein kinase 2-interacting protein 1) (CK2-interacting protein-1) (CKIP-1) (C-Jun-binding protein) (JBP) (Osteoclast maturation associated gene 120 protein) |
| CKIP1 Gene names | | PLEKHO1 (CKIP1) (OC120) (HQ0024c) |
| Organism | | Human |
| CKIP1 Entry name | | PKHO1_HUMAN |
| CKIP1 Codon optimized cDNA(gene) Clone |
| CKIP1 Cat # | | RPA0200 |
| Tag | | CKIP1 contains A 6x histidine tag |
| CKIP1 Formulation | | Liquid |
| CKIP1 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| CKIP1 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant CKIP1 Protein |
| CKIP1 Cat # | | PA0200 |
| CKIP1 Source | | recombinant |
| CKIP1 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| CKIP1 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| CKIP1 Activity | | N/A |
| Tag | | CKIP1 Contains A 6x histidine tag |
| CKIP1 Formulation | | Liquid |
| CKIP1 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CKIP1 Products | | For pricing and availability Click Here >>> |
| CKIP1 family | | - |
| CKIP1 Subcellular locations | | Cell membrane. Nucleus. Cytoplasm. |
| CKIP1 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. |
| CKIP1 Sequence | | DDBJ | EMBL | GenBank |
| CKIP1 3D structure | | ModBase |
| CKIP1 interaction | | STRING |
| CKIP1 Proteomic | | PRIDE |
| CKIP1 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| CKIP1 Organism specific | | CTD | MGI |
| CKIP1 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CKIP1 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| CKIP1 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |