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Human Pleckstrin homology domain-containing family O 1 (aa 1-409)
CKIP1 Swiss Prot#
Q53GL0
CKIP1 Protein names
Pleckstrin homology domain-containing family O member 1 (Casein kinase 2-interacting protein 1) (CK2-interacting protein-1) (CKIP-1) (C-Jun-binding protein) (JBP) (Osteoclast maturation associated gene 120 protein)
CKIP1 Gene names
PLEKHO1 (CKIP1) (OC120) (HQ0024c)
Organism
Human
CKIP1 Entry name
PKHO1_HUMAN
CKIP1 Codon optimized cDNA(gene) Clone
CKIP1 Cat #
RPA0200
Tag
CKIP1 contains A 6x histidine tag
CKIP1 Formulation
Liquid
CKIP1 Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
CKIP1 Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant CKIP1 Protein
CKIP1 Cat #
PA0200
CKIP1 Source
recombinant
CKIP1 Applications
Western Blot, SDS-Page or may be used for other applications determined by user
CKIP1 Purity
>90%, as determined by SDS-PAGE under reducing conditions
CKIP1 Activity
N/A
Tag
CKIP1 Contains A 6x histidine tag
CKIP1 Formulation
Liquid
CKIP1 Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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CKIP1 family
-
CKIP1 Subcellular locations
Cell membrane. Nucleus. Cytoplasm.
CKIP1 FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
CKIP1 Sequence
DDBJ EMBL GenBank
CKIP1 3D structure
ModBase
CKIP1 interaction
STRING
CKIP1 Proteomic
PRIDE
CKIP1 Genome annotation
Ensembl GeneID KEGG UCSC
CKIP1 Organism specific
CTD MGI
CKIP1 Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
CKIP1 Gene expression
Bgee ArrayExpress Genevestigator
CKIP1 Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY