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Human Interleukin-23 subunit alpha (aa 20-189)

SGRF Swiss Prot#

Q9NPF7

SGRF Protein names

Interleukin-23 subunit alpha (IL-23 subunit alpha) (Interleukin-23 subunit p19) (IL-23p19)

SGRF Gene names

IL23A (SGRF) (UNQ2498/PRO5798)

Organism

Human

SGRF Entry name

IL23A_HUMAN

SGRF Codon optimized cDNA(gene) Clone

SGRF Cat #

RPA0158

Tag

SGRF contains A 6x histidine tag

SGRF Formulation

Liquid

SGRF Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

SGRF Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant SGRF Protein

SGRF Cat #

PA0158

SGRF Source

recombinant

SGRF Applications

Western Blot, SDS-Page or may be used for other applications determined by user

SGRF Purity

>90%, as determined by SDS-PAGE under reducing conditions

SGRF Activity

N/A

Tag

SGRF Contains A 6x histidine tag

SGRF Formulation

Liquid

SGRF Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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SGRF family

IL-6 superfamily

SGRF Subcellular locations

Secreted.

SGRF FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

SGRF Sequence

DDBJ

EMBL

GenBank

SGRF 3D structure

ModBase

SGRF interaction

STRING

SGRF Proteomic

PRIDE

SGRF Genome annotation

Ensembl

GeneID

KEGG

UCSC

SGRF Organism specific

CTD

MGI

SGRF Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

SGRF Gene expression

Bgee

ArrayExpress

Genevestigator

SGRF Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY