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Human Interferon regulatory factor 3 (aa 1-427)

IRF3 Swiss Prot#

Q14653

IRF3 Protein names

Interferon regulatory factor 3 (IRF-3)

IRF3 Gene names

IRF3

Organism

Human

IRF3 Entry name

IRF3_HUMAN

IRF3 Codon optimized cDNA(gene) Clone

IRF3 Cat #

RPA0120

Tag

IRF3 contains A 6x histidine tag

IRF3 Formulation

Liquid

IRF3 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

IRF3 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant IRF3 Protein

IRF3 Cat #

PA0120

IRF3 Source

recombinant

IRF3 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

IRF3 Purity

>90%, as determined by SDS-PAGE under reducing conditions

IRF3 Activity

N/A

Tag

IRF3 Contains A 6x histidine tag

IRF3 Formulation

Liquid

IRF3 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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IRF3 family

IRF family

IRF3 Subcellular locations

Cytoplasm. Nucleus.

IRF3 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains.

IRF3 Sequence

DDBJ

EMBL

GenBank

IRF3 3D structure

ModBase

IRF3 interaction

STRING

IRF3 Proteomic

PRIDE

IRF3 Genome annotation

Ensembl

GeneID

KEGG

UCSC

IRF3 Organism specific

CTD

MGI

IRF3 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

IRF3 Gene expression

Bgee

ArrayExpress

Genevestigator

IRF3 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY