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| Human Histone arginine demethylase JMJD6 (aa 1-403) |
| JMJD6 Swiss Prot# | | Q6NYC1 |
| JMJD6 Protein names | | Histone arginine demethylase JMJD6 (EC 1.14.11.-) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Protein PTDSR) (Phosphatidylserine 1-receptor) |
| JMJD6 Gene names | | JMJD6 (KIAA0585) (PTDSR) |
| Organism | | Human |
| JMJD6 Entry name | | JMJD6_HUMAN |
| JMJD6 Codon optimized cDNA(gene) Clone |
| JMJD6 Cat # | | RPA0093 |
| Tag | | JMJD6 contains A 6x histidine tag |
| JMJD6 Formulation | | Liquid |
| JMJD6 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| JMJD6 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant JMJD6 Protein |
| JMJD6 Cat # | | PA0093 |
| JMJD6 Source | | recombinant |
| JMJD6 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| JMJD6 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| JMJD6 Activity | | N/A |
| Tag | | JMJD6 Contains A 6x histidine tag |
| JMJD6 Formulation | | Liquid |
| JMJD6 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant JMJD6 Products | | For pricing and availability Click Here >>> |
| JMJD6 family | | JMJD6 family |
| JMJD6 Subcellular locations | | Nucleus > nucleoplasm. Nucleus > nucleolus. |
| JMJD6 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses. |
| JMJD6 Sequence | | DDBJ | EMBL | GenBank |
| JMJD6 3D structure | | ModBase |
| JMJD6 interaction | | STRING |
| JMJD6 Proteomic | | PRIDE |
| JMJD6 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| JMJD6 Organism specific | | CTD | MGI |
| JMJD6 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| JMJD6 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| JMJD6 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
