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Human Cell adhesion molecule 1 (aa 45-442)

IGSF4 Swiss Prot#

Q9BY67

IGSF4 Protein names

Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (Nectin-like protein 2) (NECL-2) (Tumor suppressor in lung cancer 1) (TSLC-1) (Synaptic cell adhesion molecule) (Spermatogenic immunoglobulin superfamily) (SgIGSF)

IGSF4 Gene names

CADM1 (IGSF4) (NECL2) (SYNCAM) (TSLC1)

Organism

Human

IGSF4 Entry name

CADM1_HUMAN

IGSF4 Codon optimized cDNA(gene) Clone

IGSF4 Cat #

RPA0033

Tag

IGSF4 contains A 6x histidine tag

IGSF4 Formulation

Liquid

IGSF4 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

IGSF4 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant IGSF4 Protein

IGSF4 Cat #

PA0033

IGSF4 Source

recombinant

IGSF4 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

IGSF4 Purity

>90%, as determined by SDS-PAGE under reducing conditions

IGSF4 Activity

N/A

Tag

IGSF4 Contains A 6x histidine tag

IGSF4 Formulation

Liquid

IGSF4 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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IGSF4 family

Nectin family

IGSF4 Subcellular locations

Cell membrane; Single-pass type I membrane protein.

IGSF4 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.

IGSF4 Sequence

DDBJ

EMBL

GenBank

IGSF4 3D structure

ModBase

IGSF4 interaction

STRING

IGSF4 Proteomic

PRIDE

IGSF4 Genome annotation

Ensembl

GeneID

KEGG

UCSC

IGSF4 Organism specific

CTD

MGI

IGSF4 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

IGSF4 Gene expression

Bgee

ArrayExpress

Genevestigator

IGSF4 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY