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| Rat Transcription factor Maf (aa 1-369) |
| Maf2 Swiss Prot# | | P54844 |
| Maf2 Protein names | | Transcription factor Maf (Proto-oncogene c-maf) (C-Maf) (Transcription factor Maf-2) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog) |
| Maf2 Gene names | | Maf (Maf2) |
| Organism | | Rat |
| Maf2 Entry name | | MAF_RAT |
| Maf2 Codon optimized cDNA(gene) Clone |
| Maf2 Cat # | | RPW0309 |
| Tag | | Maf2 contains A 6x histidine tag |
| Maf2 Formulation | | Liquid |
| Maf2 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Maf2 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant Maf2 Protein |
| Maf2 Cat # | | PW0309 |
| Maf2 Source | | recombinant |
| Maf2 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| Maf2 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Maf2 Activity | | N/A |
| Tag | | Maf2 Contains A 6x histidine tag |
| Maf2 Formulation | | Liquid |
| Maf2 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant Maf2 Products | | For pricing and availability Click Here >>> |
| Maf2 family | | BZIP family, Maf subfamily |
| Maf2 Subcellular locations | | Nucleus. |
| Maf2 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Acts as a transcriptional activator or repressor. When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells. It may interact with additional basic-zipper proteins that determine a subtype of Maf-responsive element binding (By similarity). |
| Maf2 Sequence | | DDBJ | EMBL | GenBank |
| Maf2 3D structure | | ModBase |
| Maf2 interaction | | STRING |
| Maf2 Proteomic | | PRIDE |
| Maf2 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| Maf2 Organism specific | | CTD | MGI |
| Maf2 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| Maf2 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| Maf2 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
