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Mouse Importin subunit alpha-7 (aa 1-536)

Kpna5 Swiss Prot#

O35345

Kpna5 Protein names

Importin subunit alpha-7 (Karyopherin subunit alpha-6) (Importin alpha S2)

Kpna5 Gene names

Kpna6 (Kpna5)

Organism

Mouse

Kpna5 Entry name

IMA7_MOUSE

Kpna5 Codon optimized cDNA(gene) Clone

Kpna5 Cat #

RPW0277

Tag

Kpna5 contains A 6x histidine tag

Kpna5 Formulation

Liquid

Kpna5 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Kpna5 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Kpna5 Protein

Kpna5 Cat #

PW0277

Kpna5 Source

recombinant

Kpna5 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Kpna5 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Kpna5 Activity

N/A

Tag

Kpna5 Contains A 6x histidine tag

Kpna5 Formulation

Liquid

Kpna5 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Kpna5 family

Importin alpha family

Kpna5 Subcellular locations

Cytoplasm.

Kpna5 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Kpna5 Sequence

DDBJ

EMBL

GenBank

Kpna5 3D structure

ModBase

Kpna5 interaction

STRING

Kpna5 Proteomic

PRIDE

Kpna5 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Kpna5 Organism specific

CTD

MGI

Kpna5 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Kpna5 Gene expression

Bgee

ArrayExpress

Genevestigator

Kpna5 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY