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Mouse Importin subunit alpha-3 (aa 2-521)

Qip2 Swiss Prot#

O35344

Qip2 Protein names

Importin subunit alpha-3 (Karyopherin subunit alpha-3) (Importin alpha Q2) (Qip2)

Qip2 Gene names

Kpna3 (Qip2)

Organism

Mouse

Qip2 Entry name

IMA3_MOUSE

Qip2 Codon optimized cDNA(gene) Clone

Qip2 Cat #

RPW0273

Tag

Qip2 contains A 6x histidine tag

Qip2 Formulation

Liquid

Qip2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Qip2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Qip2 Protein

Qip2 Cat #

PW0273

Qip2 Source

recombinant

Qip2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Qip2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Qip2 Activity

N/A

Tag

Qip2 Contains A 6x histidine tag

Qip2 Formulation

Liquid

Qip2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Qip2 family

Importin alpha family

Qip2 Subcellular locations

Cytoplasm. Nucleus.

Qip2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Qip2 Sequence

DDBJ

EMBL

GenBank

Qip2 3D structure

ModBase

Qip2 interaction

STRING

Qip2 Proteomic

PRIDE

Qip2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Qip2 Organism specific

CTD

MGI

Qip2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Qip2 Gene expression

Bgee

ArrayExpress

Genevestigator

Qip2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY