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Mouse TNF receptor-associated factor 2 (aa 1-501)

Traf2 Swiss Prot#

P39429

Traf2 Protein names

TNF receptor-associated factor 2

Traf2 Gene names

Traf2

Organism

Mouse

Traf2 Entry name

TRAF2_MOUSE

Traf2 Codon optimized cDNA(gene) Clone

Traf2 Cat #

RPW0262

Tag

Traf2 contains A 6x histidine tag

Traf2 Formulation

Liquid

Traf2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Traf2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Traf2 Protein

Traf2 Cat #

PW0262

Traf2 Source

recombinant

Traf2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Traf2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Traf2 Activity

N/A

Tag

Traf2 Contains A 6x histidine tag

Traf2 Formulation

Liquid

Traf2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Traf2 family

TNF receptor-associated factor family, A subfamily

Traf2 Subcellular locations

Cytoplasm.

Traf2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Isoform 2 does not seem to mediate activation of NF-kappa-B but inhibits isoform 1 activity.

Traf2 Sequence

DDBJ

EMBL

GenBank

Traf2 3D structure

ModBase

Traf2 interaction

STRING

Traf2 Proteomic

PRIDE

Traf2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Traf2 Organism specific

CTD

MGI

Traf2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Traf2 Gene expression

Bgee

ArrayExpress

Genevestigator

Traf2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY