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Mouse Tribbles homolog 3 (aa 68-315)

Nipk Swiss Prot#

Q8K4K2

Nipk Protein names

Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase)

Nipk Gene names

Trib3 (Nipk) (Trb3)

Organism

Mouse

Nipk Entry name

TRIB3_MOUSE

Nipk Codon optimized cDNA(gene) Clone

Nipk Cat #

RPW0215

Tag

Nipk contains A 6x histidine tag

Nipk Formulation

Liquid

Nipk Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Nipk Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Nipk Protein

Nipk Cat #

PW0215

Nipk Source

recombinant

Nipk Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Nipk Purity

>90%, as determined by SDS-PAGE under reducing conditions

Nipk Activity

N/A

Tag

Nipk Contains A 6x histidine tag

Nipk Formulation

Liquid

Nipk Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Nipk family

Protein kinase superfamily, CAMK Ser/Thr protein kinase family, Tribbles subfamily

Nipk Subcellular locations

Nucleus.

Nipk FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity.

Nipk Sequence

DDBJ

EMBL

GenBank

Nipk 3D structure

ModBase

Nipk interaction

STRING

Nipk Proteomic

PRIDE

Nipk Genome annotation

Ensembl

GeneID

KEGG

UCSC

Nipk Organism specific

CTD

MGI

Nipk Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Nipk Gene expression

Bgee

ArrayExpress

Genevestigator

Nipk Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY