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Mouse Polycomb group RING finger protein 2 (aa 1-342)
Mel-18 Swiss Prot#
P23798
Mel-18 Protein names
Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (Melanoma nuclear protein 18) (RING finger protein 110) (Zinc finger protein 144) (Zfp-144)
Mel-18 Gene names
Pcgf2 (Mel-18) (Mel18) (Rnf110) (Zfp144) (Znf144)
Organism
Mouse
Mel-18 Entry name
PCGF2_MOUSE
Mel-18 Codon optimized cDNA(gene) Clone
Mel-18 Cat #
RPW0212
Tag
Mel-18 contains A 6x histidine tag
Mel-18 Formulation
Liquid
Mel-18 Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Mel-18 Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant Mel-18 Protein
Mel-18 Cat #
PW0212
Mel-18 Source
recombinant
Mel-18 Applications
Western Blot, SDS-Page or may be used for other applications determined by user
Mel-18 Purity
>90%, as determined by SDS-PAGE under reducing conditions
Mel-18 Activity
N/A
Tag
Mel-18 Contains A 6x histidine tag
Mel-18 Formulation
Liquid
Mel-18 Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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Mel-18 family
-
Mel-18 Subcellular locations
Nucleus.
Mel-18 FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Mel-18 Sequence
DDBJ EMBL GenBank
Mel-18 3D structure
ModBase
Mel-18 interaction
STRING
Mel-18 Proteomic
PRIDE
Mel-18 Genome annotation
Ensembl GeneID KEGG UCSC
Mel-18 Organism specific
CTD MGI
Mel-18 Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
Mel-18 Gene expression
Bgee ArrayExpress Genevestigator
Mel-18 Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY