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Human H ACA ribonucleoprotein complex subunit 4 (aa 2-514)

NOLA4 Swiss Prot#

O60832

NOLA4 Protein names

H/ACA ribonucleoprotein complex subunit 4 (EC 5.4.99.-) (Dyskerin) (Nucleolar protein family A member 4) (snoRNP protein DKC1) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (CBF5 homolog)

NOLA4 Gene names

DKC1 (NOLA4)

Organism

Human

NOLA4 Entry name

DKC1_HUMAN

NOLA4 Codon optimized cDNA(gene) Clone

NOLA4 Cat #

RPW0120

Tag

NOLA4 contains A 6x histidine tag

NOLA4 Formulation

Liquid

NOLA4 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

NOLA4 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant NOLA4 Protein

NOLA4 Cat #

PW0120

NOLA4 Source

recombinant

NOLA4 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

NOLA4 Purity

>90%, as determined by SDS-PAGE under reducing conditions

NOLA4 Activity

N/A

Tag

NOLA4 Contains A 6x histidine tag

NOLA4 Formulation

Liquid

NOLA4 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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NOLA4 family

Pseudouridine synthase TruB family

NOLA4 Subcellular locations

Nucleus > nucleolus. Nucleus > Cajal body.

NOLA4 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.

NOLA4 Sequence

DDBJ

EMBL

GenBank

NOLA4 3D structure

ModBase

NOLA4 interaction

STRING

NOLA4 Proteomic

PRIDE

NOLA4 Genome annotation

Ensembl

GeneID

KEGG

UCSC

NOLA4 Organism specific

CTD

MGI

NOLA4 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

NOLA4 Gene expression

Bgee

ArrayExpress

Genevestigator

NOLA4 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY