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Human WW domain-containing transcription regulator 1 (aa 1-400)

TAZ Swiss Prot#

Q9GZV5

TAZ Protein names

WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)

TAZ Gene names

WWTR1 (TAZ)

Organism

Human

TAZ Entry name

WWTR1_HUMAN

TAZ Codon optimized cDNA(gene) Clone

TAZ Cat #

RPW0090

Tag

TAZ contains A 6x histidine tag

TAZ Formulation

Liquid

TAZ Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

TAZ Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant TAZ Protein

TAZ Cat #

PW0090

TAZ Source

recombinant

TAZ Applications

Western Blot, SDS-Page or may be used for other applications determined by user

TAZ Purity

>90%, as determined by SDS-PAGE under reducing conditions

TAZ Activity

N/A

Tag

TAZ Contains A 6x histidine tag

TAZ Formulation

Liquid

TAZ Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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TAZ family

-

TAZ Subcellular locations

Nucleus. Cytoplasm.

TAZ FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

TAZ Sequence

DDBJ

EMBL

GenBank

TAZ 3D structure

ModBase

TAZ interaction

STRING

TAZ Proteomic

PRIDE

TAZ Genome annotation

Ensembl

GeneID

KEGG

UCSC

TAZ Organism specific

CTD

MGI

TAZ Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

TAZ Gene expression

Bgee

ArrayExpress

Genevestigator

TAZ Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY