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| Human DNA dC->dU-editing enzyme APOBEC-3G (aa 1-384) |
| MDS019 Swiss Prot# | | Q9HC16 |
| MDS019 Protein names | | DNA dC->dU-editing enzyme APOBEC-3G (EC 3.5.4.-) (APOBEC-related cytidine deaminase) (ARCD) (APOBEC-related protein) (ARP-9) (CEM-15) (CEM15) |
| MDS019 Gene names | | APOBEC3G (MDS019) |
| Organism | | Human |
| MDS019 Entry name | | ABC3G_HUMAN |
| MDS019 Codon optimized cDNA(gene) Clone |
| MDS019 Cat # | | RPW0085 |
| Tag | | MDS019 contains A 6x histidine tag |
| MDS019 Formulation | | Liquid |
| MDS019 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| MDS019 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant MDS019 Protein |
| MDS019 Cat # | | PW0085 |
| MDS019 Source | | recombinant |
| MDS019 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| MDS019 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| MDS019 Activity | | N/A |
| Tag | | MDS019 Contains A 6x histidine tag |
| MDS019 Formulation | | Liquid |
| MDS019 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant MDS019 Products | | For pricing and availability Click Here >>> |
| MDS019 family | | Cytidine and deoxycytidylate deaminase family |
| MDS019 Subcellular locations | | Cytoplasm. Nucleus. |
| MDS019 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: DNA deaminase (cytidine deaminase) that mediates a form of innate resistance to retroviral infections (at least to HIV-1 infection) by triggering G-to-A hypermutation in the newly synthesized viral DNA. The replacements C-to-U in the minus strand DNA of HIV-1 during reverse transcription, leads to G-to-A transitions in the plus strand. The inhibition of viral replication is either due to the degradation of the minus strand before its integration or to the lethality of the hypermutations. Modification of both DNA strands is not excluded. This antiviral activity is neutralized by the virion infectivity factor (VIF), that prevents the incorporation of APOBEC3G into progeny HIV-1 virions by both inhibiting its translation and/or by inducing its ubiquitination and subsequent degradation by the 26S proteasome. APOBEC3G binds a variety of RNAs, but does not display detectable APOB, NF1 and NAT1 mRNA editing. |
| MDS019 Sequence | | DDBJ | EMBL | GenBank |
| MDS019 3D structure | | ModBase |
| MDS019 interaction | | STRING |
| MDS019 Proteomic | | PRIDE |
| MDS019 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| MDS019 Organism specific | | CTD | MGI |
| MDS019 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| MDS019 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| MDS019 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |