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Human DNA dC->dU-editing enzyme APOBEC-3G (aa 1-384)
MDS019 Swiss Prot#
Q9HC16
MDS019 Protein names
DNA dC->dU-editing enzyme APOBEC-3G (EC 3.5.4.-) (APOBEC-related cytidine deaminase) (ARCD) (APOBEC-related protein) (ARP-9) (CEM-15) (CEM15)
MDS019 Gene names
APOBEC3G (MDS019)
Organism
Human
MDS019 Entry name
ABC3G_HUMAN
MDS019 Codon optimized cDNA(gene) Clone
MDS019 Cat #
RPW0085
Tag
MDS019 contains A 6x histidine tag
MDS019 Formulation
Liquid
MDS019 Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
MDS019 Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant MDS019 Protein
MDS019 Cat #
PW0085
MDS019 Source
recombinant
MDS019 Applications
Western Blot, SDS-Page or may be used for other applications determined by user
MDS019 Purity
>90%, as determined by SDS-PAGE under reducing conditions
MDS019 Activity
N/A
Tag
MDS019 Contains A 6x histidine tag
MDS019 Formulation
Liquid
MDS019 Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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MDS019 family
Cytidine and deoxycytidylate deaminase family
MDS019 Subcellular locations
Cytoplasm. Nucleus.
MDS019 FUNCTION According to UniProtKB Swiss Prot
FUNCTION: DNA deaminase (cytidine deaminase) that mediates a form of innate resistance to retroviral infections (at least to HIV-1 infection) by triggering G-to-A hypermutation in the newly synthesized viral DNA. The replacements C-to-U in the minus strand DNA of HIV-1 during reverse transcription, leads to G-to-A transitions in the plus strand. The inhibition of viral replication is either due to the degradation of the minus strand before its integration or to the lethality of the hypermutations. Modification of both DNA strands is not excluded. This antiviral activity is neutralized by the virion infectivity factor (VIF), that prevents the incorporation of APOBEC3G into progeny HIV-1 virions by both inhibiting its translation and/or by inducing its ubiquitination and subsequent degradation by the 26S proteasome. APOBEC3G binds a variety of RNAs, but does not display detectable APOB, NF1 and NAT1 mRNA editing.
MDS019 Sequence
DDBJ EMBL GenBank
MDS019 3D structure
ModBase
MDS019 interaction
STRING
MDS019 Proteomic
PRIDE
MDS019 Genome annotation
Ensembl GeneID KEGG UCSC
MDS019 Organism specific
CTD MGI
MDS019 Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
MDS019 Gene expression
Bgee ArrayExpress Genevestigator
MDS019 Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY