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Human Toll-like receptor 4 (aa 24–631)

TLR4 Swiss Prot#

O00206

TLR4 Protein names

Toll-like receptor 4 (hToll) (CD antigen CD284)

TLR4 Gene names

TLR4

Organism

Human

TLR4 Entry name

TLR4_HUMAN

TLR4 Codon optimized cDNA(gene) Clone

TLR4 Cat #

RPE0864

Tag

TLR4 contains A 6x histidine tag

TLR4 Formulation

Liquid

TLR4 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

TLR4 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant TLR4 Protein

TLR4 Cat #

PE0864

TLR4 Source

recombinant

TLR4 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

TLR4 Purity

>90%, as determined by SDS-PAGE under reducing conditions

TLR4 Activity

N/A

Tag

TLR4 Contains A 6x histidine tag

TLR4 Formulation

Liquid

TLR4 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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TLR4 family

Toll-like receptor family

TLR4 Subcellular locations

Membrane; Single-pass type I membrane protein.

TLR4 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by Ni(2+). These responses require non-conserved histidines and are, therefore, species-specific.

TLR4 Sequence

DDBJ

EMBL

GenBank

TLR4 3D structure

ModBase

TLR4 interaction

STRING

TLR4 Proteomic

PRIDE

TLR4 Genome annotation

Ensembl

GeneID

KEGG

UCSC

TLR4 Organism specific

CTD

MGI

TLR4 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

TLR4 Gene expression

Bgee

ArrayExpress

Genevestigator

TLR4 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY