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Human Transitional endoplasmic reticulum ATPase (aa 1-350)

VCP Swiss Prot#

P55072

VCP Protein names

Transitional endoplasmic reticulum ATPase (TER ATPase) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP)

VCP Gene names

VCP

Organism

Human

VCP Entry name

TERA_HUMAN

VCP Codon optimized cDNA(gene) Clone

VCP Cat #

RPE0861

Tag

VCP contains A 6x histidine tag

VCP Formulation

Liquid

VCP Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

VCP Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant VCP Protein

VCP Cat #

PE0861

VCP Source

recombinant

VCP Applications

Western Blot, SDS-Page or may be used for other applications determined by user

VCP Purity

>90%, as determined by SDS-PAGE under reducing conditions

VCP Activity

N/A

Tag

VCP Contains A 6x histidine tag

VCP Formulation

Liquid

VCP Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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VCP family

AAA ATPase family

VCP Subcellular locations

Cytoplasm > cytosol. Nucleus.

VCP FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Regulates E3 ubiquitin-protein ligase activity of RNF19A.

VCP Sequence

DDBJ

EMBL

GenBank

VCP 3D structure

ModBase

VCP interaction

STRING

VCP Proteomic

PRIDE

VCP Genome annotation

Ensembl

GeneID

KEGG

UCSC

VCP Organism specific

CTD

MGI

VCP Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

VCP Gene expression

Bgee

ArrayExpress

Genevestigator

VCP Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY