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Human SHC-transforming protein 1 (aa 1–583)

SHC Swiss Prot#

P29353

SHC Protein names

SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)

SHC Gene names

SHC1 (SHC) (SHCA)

Organism

Human

SHC Entry name

SHC1_HUMAN

SHC Codon optimized cDNA(gene) Clone

SHC Cat #

RPE0854

Tag

SHC contains A 6x histidine tag

SHC Formulation

Liquid

SHC Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

SHC Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant SHC Protein

SHC Cat #

PE0854

SHC Source

recombinant

SHC Applications

Western Blot, SDS-Page or may be used for other applications determined by user

SHC Purity

>90%, as determined by SDS-PAGE under reducing conditions

SHC Activity

N/A

Tag

SHC Contains A 6x histidine tag

SHC Formulation

Liquid

SHC Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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SHC family

-

SHC Subcellular locations

Cytoplasm. Mitochondrion matrix. Mitochondrion.

SHC FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity).

SHC Sequence

DDBJ

EMBL

GenBank

SHC 3D structure

ModBase

SHC interaction

STRING

SHC Proteomic

PRIDE

SHC Genome annotation

Ensembl

GeneID

KEGG

UCSC

SHC Organism specific

CTD

MGI

SHC Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

SHC Gene expression

Bgee

ArrayExpress

Genevestigator

SHC Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY