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| Human Platelet endothelial cell adhesion molecule (aa 28–601) |
| PECAM1 Swiss Prot# | | P16284 |
| PECAM1 Protein names | | Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (CD antigen CD31) |
| PECAM1 Gene names | | PECAM1 |
| Organism | | Human |
| PECAM1 Entry name | | PECA1_HUMAN |
| PECAM1 Codon optimized cDNA(gene) Clone |
| PECAM1 Cat # | | RPE0850 |
| Tag | | PECAM1 contains A 6x histidine tag |
| PECAM1 Formulation | | Liquid |
| PECAM1 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| PECAM1 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant PECAM1 Protein |
| PECAM1 Cat # | | PE0850 |
| PECAM1 Source | | recombinant |
| PECAM1 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| PECAM1 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| PECAM1 Activity | | N/A |
| Tag | | PECAM1 Contains A 6x histidine tag |
| PECAM1 Formulation | | Liquid |
| PECAM1 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant PECAM1 Products | | For pricing and availability Click Here >>> |
| PECAM1 family | | - |
| PECAM1 Subcellular locations | | Membrane; Single-pass type I membrane protein. Cell junction. Cell junction. |
| PECAM1 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC). |
| PECAM1 Sequence | | DDBJ | EMBL | GenBank |
| PECAM1 3D structure | | ModBase |
| PECAM1 interaction | | STRING |
| PECAM1 Proteomic | | PRIDE |
| PECAM1 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| PECAM1 Organism specific | | CTD | MGI |
| PECAM1 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| PECAM1 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| PECAM1 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
