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Human Serine threonine-protein kinase Chk2 (aa 220–486)

CHK2 Swiss Prot#

O96017

CHK2 Protein names

Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1)

CHK2 Gene names

CHEK2 (CHK2) (RAD53)

Organism

Human

CHK2 Entry name

CHK2_HUMAN

CHK2 Codon optimized cDNA(gene) Clone

CHK2 Cat #

RPE0826

Tag

CHK2 contains A 6x histidine tag

CHK2 Formulation

Liquid

CHK2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CHK2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CHK2 Protein

CHK2 Cat #

PE0826

CHK2 Source

recombinant

CHK2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CHK2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

CHK2 Activity

N/A

Tag

CHK2 Contains A 6x histidine tag

CHK2 Formulation

Liquid

CHK2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CHK2 family

Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CHK2 subfamily

CHK2 Subcellular locations

Nucleus. Nucleus > PML body. Nucleus > nucleoplasm.

CHK2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'.

CHK2 Sequence

DDBJ

EMBL

GenBank

CHK2 3D structure

ModBase

CHK2 interaction

STRING

CHK2 Proteomic

PRIDE

CHK2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

CHK2 Organism specific

CTD

MGI

CHK2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CHK2 Gene expression

Bgee

ArrayExpress

Genevestigator

CHK2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY