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Human E3 ubiquitin-protein ligase Mdm2 (aa 1–491)

MDM2 Swiss Prot#

Q00987

MDM2 Protein names

E3 ubiquitin-protein ligase Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2)

MDM2 Gene names

MDM2

Organism

Human

MDM2 Entry name

MDM2_HUMAN

MDM2 Codon optimized cDNA(gene) Clone

MDM2 Cat #

RPE0773

Tag

MDM2 contains A 6x histidine tag

MDM2 Formulation

Liquid

MDM2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

MDM2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant MDM2 Protein

MDM2 Cat #

PE0773

MDM2 Source

recombinant

MDM2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

MDM2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

MDM2 Activity

N/A

Tag

MDM2 Contains A 6x histidine tag

MDM2 Formulation

Liquid

MDM2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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MDM2 family

MDM2/MDM4 family

MDM2 Subcellular locations

Nucleus > nucleoplasm. Cytoplasm. Nucleus > nucleolus.

MDM2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways.

MDM2 Sequence

DDBJ

EMBL

GenBank

MDM2 3D structure

ModBase

MDM2 interaction

STRING

MDM2 Proteomic

PRIDE

MDM2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

MDM2 Organism specific

CTD

MGI

MDM2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

MDM2 Gene expression

Bgee

ArrayExpress

Genevestigator

MDM2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY