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Human Sterol regulatory element-binding protein 1 (aa 1–490)

SREBP1 Swiss Prot#

P36956

SREBP1 Protein names

Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1]

SREBP1 Gene names

SREBF1 (SREBP1)

Organism

Human

SREBP1 Entry name

SRBP1_HUMAN

SREBP1 Codon optimized cDNA(gene) Clone

SREBP1 Cat #

RPE0772

Tag

SREBP1 contains A 6x histidine tag

SREBP1 Formulation

Liquid

SREBP1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

SREBP1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant SREBP1 Protein

SREBP1 Cat #

PE0772

SREBP1 Source

recombinant

SREBP1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

SREBP1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

SREBP1 Activity

N/A

Tag

SREBP1 Contains A 6x histidine tag

SREBP1 Formulation

Liquid

SREBP1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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SREBP1 family

SREBP family

SREBP1 Subcellular locations

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle > COPII-coated vesicle membrane; Multi-pass membrane protein. Nucleus.

SREBP1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').

SREBP1 Sequence

DDBJ

EMBL

GenBank

SREBP1 3D structure

ModBase

SREBP1 interaction

STRING

SREBP1 Proteomic

PRIDE

SREBP1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

SREBP1 Organism specific

CTD

MGI

SREBP1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

SREBP1 Gene expression

Bgee

ArrayExpress

Genevestigator

SREBP1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY