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Human Eukaryotic translation initiation factor 2-alpha kinase 3 (aa 592–1076)

PEK Swiss Prot#

Q9NZJ5

PEK Protein names

Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK)

PEK Gene names

EIF2AK3 (PEK) (PERK)

Organism

Human

PEK Entry name

E2AK3_HUMAN

PEK Codon optimized cDNA(gene) Clone

PEK Cat #

RPE0765

Tag

PEK contains A 6x histidine tag

PEK Formulation

Liquid

PEK Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PEK Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PEK Protein

PEK Cat #

PE0765

PEK Source

recombinant

PEK Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PEK Purity

>90%, as determined by SDS-PAGE under reducing conditions

PEK Activity

N/A

Tag

PEK Contains A 6x histidine tag

PEK Formulation

Liquid

PEK Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PEK family

Protein kinase superfamily, Ser/Thr protein kinase family, GCN2 subfamily

PEK Subcellular locations

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

PEK FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1 (By similarity).

PEK Sequence

DDBJ

EMBL

GenBank

PEK 3D structure

ModBase

PEK interaction

STRING

PEK Proteomic

PRIDE

PEK Genome annotation

Ensembl

GeneID

KEGG

UCSC

PEK Organism specific

CTD

MGI

PEK Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PEK Gene expression

Bgee

ArrayExpress

Genevestigator

PEK Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY