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Human Caspase-8 (aa 217–374)

MCH5 Swiss Prot#

Q14790

MCH5 Protein names

Caspase-8 (CASP-8) (EC 3.4.22.61) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]

MCH5 Gene names

CASP8 (MCH5)

Organism

Human

MCH5 Entry name

CASP8_HUMAN

MCH5 Codon optimized cDNA(gene) Clone

MCH5 Cat #

RPE0759

Tag

MCH5 contains A 6x histidine tag

MCH5 Formulation

Liquid

MCH5 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

MCH5 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant MCH5 Protein

MCH5 Cat #

PE0759

MCH5 Source

recombinant

MCH5 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

MCH5 Purity

>90%, as determined by SDS-PAGE under reducing conditions

MCH5 Activity

N/A

Tag

MCH5 Contains A 6x histidine tag

MCH5 Formulation

Liquid

MCH5 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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MCH5 family

Peptidase C14A family

MCH5 Subcellular locations

Cytoplasm.

MCH5 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.

MCH5 Sequence

DDBJ

EMBL

GenBank

MCH5 3D structure

ModBase

MCH5 interaction

STRING

MCH5 Proteomic

PRIDE

MCH5 Genome annotation

Ensembl

GeneID

KEGG

UCSC

MCH5 Organism specific

CTD

MGI

MCH5 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

MCH5 Gene expression

Bgee

ArrayExpress

Genevestigator

MCH5 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY