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| Human Mothers against decapentaplegic homolog 2 (aa 2–467) |
| MADH2 Swiss Prot# | | Q15796 |
| MADH2 Protein names | | Mothers against decapentaplegic homolog 2 (Mothers against DPP homolog 2) (Mad-related protein 2) (hMAD-2) (SMAD 2) (hSMAD2) (JV18-1) |
| MADH2 Gene names | | SMAD2 (MADH2) (MADR2) |
| Organism | | Human |
| MADH2 Entry name | | SMAD2_HUMAN |
| MADH2 Codon optimized cDNA(gene) Clone |
| MADH2 Cat # | | RPE0749 |
| Tag | | MADH2 contains A 6x histidine tag |
| MADH2 Formulation | | Liquid |
| MADH2 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| MADH2 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant MADH2 Protein |
| MADH2 Cat # | | PE0749 |
| MADH2 Source | | recombinant |
| MADH2 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| MADH2 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| MADH2 Activity | | N/A |
| Tag | | MADH2 Contains A 6x histidine tag |
| MADH2 Formulation | | Liquid |
| MADH2 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant MADH2 Products | | For pricing and availability Click Here >>> |
| MADH2 family | | Dwarfin/SMAD family |
| MADH2 Subcellular locations | | Cytoplasm. Nucleus. |
| MADH2 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. |
| MADH2 Sequence | | DDBJ | EMBL | GenBank |
| MADH2 3D structure | | ModBase |
| MADH2 interaction | | STRING |
| MADH2 Proteomic | | PRIDE |
| MADH2 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| MADH2 Organism specific | | CTD | MGI |
| MADH2 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| MADH2 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| MADH2 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |