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Human Mothers against decapentaplegic homolog 2 (aa 2–467)
MADH2 Swiss Prot#
Q15796
MADH2 Protein names
Mothers against decapentaplegic homolog 2 (Mothers against DPP homolog 2) (Mad-related protein 2) (hMAD-2) (SMAD 2) (hSMAD2) (JV18-1)
MADH2 Gene names
SMAD2 (MADH2) (MADR2)
Organism
Human
MADH2 Entry name
SMAD2_HUMAN
MADH2 Codon optimized cDNA(gene) Clone
MADH2 Cat #
RPE0749
Tag
MADH2 contains A 6x histidine tag
MADH2 Formulation
Liquid
MADH2 Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
MADH2 Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant MADH2 Protein
MADH2 Cat #
PE0749
MADH2 Source
recombinant
MADH2 Applications
Western Blot, SDS-Page or may be used for other applications determined by user
MADH2 Purity
>90%, as determined by SDS-PAGE under reducing conditions
MADH2 Activity
N/A
Tag
MADH2 Contains A 6x histidine tag
MADH2 Formulation
Liquid
MADH2 Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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MADH2 family
Dwarfin/SMAD family
MADH2 Subcellular locations
Cytoplasm. Nucleus.
MADH2 FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma.
MADH2 Sequence
DDBJ EMBL GenBank
MADH2 3D structure
ModBase
MADH2 interaction
STRING
MADH2 Proteomic
PRIDE
MADH2 Genome annotation
Ensembl GeneID KEGG UCSC
MADH2 Organism specific
CTD MGI
MADH2 Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
MADH2 Gene expression
Bgee ArrayExpress Genevestigator
MADH2 Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY