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Human Presenilin-1 (aa 1–298)

AD3 Swiss Prot#

P49768

AD3 Protein names

Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]

AD3 Gene names

PSEN1 (AD3) (PS1) (PSNL1)

Organism

Human

AD3 Entry name

PSN1_HUMAN

AD3 Codon optimized cDNA(gene) Clone

AD3 Cat #

RPE0748

Tag

AD3 contains A 6x histidine tag

AD3 Formulation

Liquid

AD3 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

AD3 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant AD3 Protein

AD3 Cat #

PE0748

AD3 Source

recombinant

AD3 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

AD3 Purity

>90%, as determined by SDS-PAGE under reducing conditions

AD3 Activity

N/A

Tag

AD3 Contains A 6x histidine tag

AD3 Formulation

Liquid

AD3 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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AD3 family

Peptidase A22A family

AD3 Subcellular locations

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell surface.

AD3 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.

AD3 Sequence

DDBJ

EMBL

GenBank

AD3 3D structure

ModBase

AD3 interaction

STRING

AD3 Proteomic

PRIDE

AD3 Genome annotation

Ensembl

GeneID

KEGG

UCSC

AD3 Organism specific

CTD

MGI

AD3 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

AD3 Gene expression

Bgee

ArrayExpress

Genevestigator

AD3 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY