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Human E3 ubiquitin-protein ligase parkin (aa 1–465)

PRKN Swiss Prot#

O60260

PRKN Protein names

E3 ubiquitin-protein ligase parkin (EC 6.3.2.-) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)

PRKN Gene names

PARK2 (PRKN)

Organism

Human

PRKN Entry name

PRKN2_HUMAN

PRKN Codon optimized cDNA(gene) Clone

PRKN Cat #

RPE0745

Tag

PRKN contains A 6x histidine tag

PRKN Formulation

Liquid

PRKN Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PRKN Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PRKN Protein

PRKN Cat #

PE0745

PRKN Source

recombinant

PRKN Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PRKN Purity

>90%, as determined by SDS-PAGE under reducing conditions

PRKN Activity

N/A

Tag

PRKN Contains A 6x histidine tag

PRKN Formulation

Liquid

PRKN Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PRKN family

RBR family, Parkin subfamily

PRKN Subcellular locations

Cytoplasm. Nucleus. Endoplasmic reticulum. Cytoplasm > cytosol.

PRKN FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include SYT11, CCNE1, GPR37, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5, ZNF746 and AIMP2. May play a more general role in the ubiquitin proteasomal pathway by participating in the removal and/or detoxification of abnormally folded or damaged protein. Limits the production of reactive oxygen species (ROS). Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of PARK2. Promotes the autophagic degradation of dysfunctional depolarized mitochondria. Mediates 'Lys-48'-linked polyubiquitination of ZNF746, followed by degradation of ZNF746 by the proteasome; possibly playing a role in role in regulation of neuron death. May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Regulates cyclin E during neuronal apoptosis. May represent a tumor suppressor gene.

PRKN Sequence

DDBJ

EMBL

GenBank

PRKN 3D structure

ModBase

PRKN interaction

STRING

PRKN Proteomic

PRIDE

PRKN Genome annotation

Ensembl

GeneID

KEGG

UCSC

PRKN Organism specific

CTD

MGI

PRKN Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PRKN Gene expression

Bgee

ArrayExpress

Genevestigator

PRKN Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY