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Human Glucokinase (aa 1–465)

GCK Swiss Prot#

P35557

GCK Protein names

Glucokinase (EC 2.7.1.2) (Hexokinase type IV) (HK IV) (Hexokinase-4) (HK4) (Hexokinase-D)

GCK Gene names

GCK

Organism

Human

GCK Entry name

HXK4_HUMAN

GCK Codon optimized cDNA(gene) Clone

GCK Cat #

RPE0744

Tag

GCK contains A 6x histidine tag

GCK Formulation

Liquid

GCK Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

GCK Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant GCK Protein

GCK Cat #

PE0744

GCK Source

recombinant

GCK Applications

Western Blot, SDS-Page or may be used for other applications determined by user

GCK Purity

>90%, as determined by SDS-PAGE under reducing conditions

GCK Activity

N/A

Tag

GCK Contains A 6x histidine tag

GCK Formulation

Liquid

GCK Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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GCK family

Hexokinase family

GCK Subcellular locations

-

GCK FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.

GCK Sequence

DDBJ

EMBL

GenBank

GCK 3D structure

ModBase

GCK interaction

STRING

GCK Proteomic

PRIDE

GCK Genome annotation

Ensembl

GeneID

KEGG

UCSC

GCK Organism specific

CTD

MGI

GCK Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

GCK Gene expression

Bgee

ArrayExpress

Genevestigator

GCK Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY