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Human Sonic hedgehog protein (aa 24–197)

SHH Swiss Prot#

Q15465

SHH Protein names

Sonic hedgehog protein (SHH) (HHG-1) [Cleaved into: Sonic hedgehog protein N-product; Sonic hedgehog protein C-product]

SHH Gene names

SHH

Organism

Human

SHH Entry name

SHH_HUMAN

SHH Codon optimized cDNA(gene) Clone

SHH Cat #

RPE0742

Tag

SHH contains A 6x histidine tag

SHH Formulation

Liquid

SHH Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

SHH Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant SHH Protein

SHH Cat #

PE0742

SHH Source

recombinant

SHH Applications

Western Blot, SDS-Page or may be used for other applications determined by user

SHH Purity

>90%, as determined by SDS-PAGE under reducing conditions

SHH Activity

N/A

Tag

SHH Contains A 6x histidine tag

SHH Formulation

Liquid

SHH Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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SHH family

Hedgehog family

SHH Subcellular locations

Secreted > extracellular space. Cell membrane; Lipid-anchor.

SHH FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction (By similarity).

SHH Sequence

DDBJ

EMBL

GenBank

SHH 3D structure

ModBase

SHH interaction

STRING

SHH Proteomic

PRIDE

SHH Genome annotation

Ensembl

GeneID

KEGG

UCSC

SHH Organism specific

CTD

MGI

SHH Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

SHH Gene expression

Bgee

ArrayExpress

Genevestigator

SHH Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY