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Human Retinoic acid receptor RXR-alpha (aa 1–462)

NR2B1 Swiss Prot#

P19793

NR2B1 Protein names

Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha) (Nuclear receptor subfamily 2 group B member 1)

NR2B1 Gene names

RXRA (NR2B1)

Organism

Human

NR2B1 Entry name

RXRA_HUMAN

NR2B1 Codon optimized cDNA(gene) Clone

NR2B1 Cat #

RPE0741

Tag

NR2B1 contains A 6x histidine tag

NR2B1 Formulation

Liquid

NR2B1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

NR2B1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant NR2B1 Protein

NR2B1 Cat #

PE0741

NR2B1 Source

recombinant

NR2B1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

NR2B1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

NR2B1 Activity

N/A

Tag

NR2B1 Contains A 6x histidine tag

NR2B1 Formulation

Liquid

NR2B1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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NR2B1 family

Nuclear hormone receptor family, NR2 subfamily

NR2B1 Subcellular locations

Nucleus.

NR2B1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.

NR2B1 Sequence

DDBJ

EMBL

GenBank

NR2B1 3D structure

ModBase

NR2B1 interaction

STRING

NR2B1 Proteomic

PRIDE

NR2B1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

NR2B1 Organism specific

CTD

MGI

NR2B1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

NR2B1 Gene expression

Bgee

ArrayExpress

Genevestigator

NR2B1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY