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Human Retinoic acid receptor alpha (aa 1–462)

NR1B1 Swiss Prot#

P10276

NR1B1 Protein names

Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1)

NR1B1 Gene names

RARA (NR1B1)

Organism

Human

NR1B1 Entry name

RARA_HUMAN

NR1B1 Codon optimized cDNA(gene) Clone

NR1B1 Cat #

RPE0740

Tag

NR1B1 contains A 6x histidine tag

NR1B1 Formulation

Liquid

NR1B1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

NR1B1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant NR1B1 Protein

NR1B1 Cat #

PE0740

NR1B1 Source

recombinant

NR1B1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

NR1B1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

NR1B1 Activity

N/A

Tag

NR1B1 Contains A 6x histidine tag

NR1B1 Formulation

Liquid

NR1B1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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NR1B1 family

Nuclear hormone receptor family, NR1 subfamily

NR1B1 Subcellular locations

Nucleus. Cytoplasm.

NR1B1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing MLL5. Mediates retinoic acid-induced granulopoiesis.

NR1B1 Sequence

DDBJ

EMBL

GenBank

NR1B1 3D structure

ModBase

NR1B1 interaction

STRING

NR1B1 Proteomic

PRIDE

NR1B1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

NR1B1 Organism specific

CTD

MGI

NR1B1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

NR1B1 Gene expression

Bgee

ArrayExpress

Genevestigator

NR1B1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY