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Human Tumor necrosis factor receptor superfamily 1B (aa 23–257)

TNFBR Swiss Prot#

P20333

TNFBR Protein names

Tumor necrosis factor receptor superfamily member 1B (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (TNF-RII) (TNFR-II) (p75) (p80 TNF-alpha receptor) (CD antigen CD120b) (Etanercept) [Cleaved into: Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2 (TBPII) (TBP-2)]

TNFBR Gene names

TNFRSF1B (TNFBR) (TNFR2)

Organism

Human

TNFBR Entry name

TNR1B_HUMAN

TNFBR Codon optimized cDNA(gene) Clone

TNFBR Cat #

RPE0739

Tag

TNFBR contains A 6x histidine tag

TNFBR Formulation

Liquid

TNFBR Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

TNFBR Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant TNFBR Protein

TNFBR Cat #

PE0739

TNFBR Source

recombinant

TNFBR Applications

Western Blot, SDS-Page or may be used for other applications determined by user

TNFBR Purity

>90%, as determined by SDS-PAGE under reducing conditions

TNFBR Activity

N/A

Tag

TNFBR Contains A 6x histidine tag

TNFBR Formulation

Liquid

TNFBR Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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TNFBR family

-

TNFBR Subcellular locations

Cell membrane; Single-pass type I membrane protein. Secreted.

TNFBR FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

TNFBR Sequence

DDBJ

EMBL

GenBank

TNFBR 3D structure

ModBase

TNFBR interaction

STRING

TNFBR Proteomic

PRIDE

TNFBR Genome annotation

Ensembl

GeneID

KEGG

UCSC

TNFBR Organism specific

CTD

MGI

TNFBR Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

TNFBR Gene expression

Bgee

ArrayExpress

Genevestigator

TNFBR Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY