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Human Disintegrin metalloproteinase domain-containing 17 (aa 215–671)
CSVP Swiss Prot#
P78536
CSVP Protein names
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (TNF-alpha-converting enzyme) (TNF-alpha convertase) (Snake venom-like protease) (CD antigen CD156b)
CSVP Gene names
ADAM17 (CSVP) (TACE)
Organism
Human
CSVP Entry name
ADA17_HUMAN
CSVP Codon optimized cDNA(gene) Clone
CSVP Cat #
RPE0736
Tag
CSVP contains A 6x histidine tag
CSVP Formulation
Liquid
CSVP Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
CSVP Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant CSVP Protein
CSVP Cat #
PE0736
CSVP Source
recombinant
CSVP Applications
Western Blot, SDS-Page or may be used for other applications determined by user
CSVP Purity
>90%, as determined by SDS-PAGE under reducing conditions
CSVP Activity
N/A
Tag
CSVP Contains A 6x histidine tag
CSVP Formulation
Liquid
CSVP Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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CSVP family
-
CSVP Subcellular locations
Membrane; Single-pass type I membrane protein.
CSVP FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity).
CSVP Sequence
DDBJ EMBL GenBank
CSVP 3D structure
ModBase
CSVP interaction
STRING
CSVP Proteomic
PRIDE
CSVP Genome annotation
Ensembl GeneID KEGG UCSC
CSVP Organism specific
CTD MGI
CSVP Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
CSVP Gene expression
Bgee ArrayExpress Genevestigator
CSVP Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY