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Human B-cell linker protein (aa 1–456)

BASH Swiss Prot#

Q8WV28

BASH Protein names

B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65)

BASH Gene names

BLNK (BASH) (SLP65)

Organism

Human

BASH Entry name

BLNK_HUMAN

BASH Codon optimized cDNA(gene) Clone

BASH Cat #

RPE0735

Tag

BASH contains A 6x histidine tag

BASH Formulation

Liquid

BASH Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

BASH Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant BASH Protein

BASH Cat #

PE0735

BASH Source

recombinant

BASH Applications

Western Blot, SDS-Page or may be used for other applications determined by user

BASH Purity

>90%, as determined by SDS-PAGE under reducing conditions

BASH Activity

N/A

Tag

BASH Contains A 6x histidine tag

BASH Formulation

Liquid

BASH Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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BASH family

-

BASH Subcellular locations

Cytoplasm. Cell membrane.

BASH FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Functions as a central linker protein that bridges kinases associated with the B-cell receptor (BCR) with a multitude of signaling pathways, regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition (By similarity). Plays an important role in BCR-induced B-cell apoptosis.

BASH Sequence

DDBJ

EMBL

GenBank

BASH 3D structure

ModBase

BASH interaction

STRING

BASH Proteomic

PRIDE

BASH Genome annotation

Ensembl

GeneID

KEGG

UCSC

BASH Organism specific

CTD

MGI

BASH Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

BASH Gene expression

Bgee

ArrayExpress

Genevestigator

BASH Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY