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Human Presenilin-2 (aa 1–297)

AD4 Swiss Prot#

P49810

AD4 Protein names

Presenilin-2 (PS-2) (EC 3.4.23.-) (STM-2) (E5-1) (AD3LP) (AD5) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit]

AD4 Gene names

PSEN2 (AD4) (PS2) (PSNL2) (STM2)

Organism

Human

AD4 Entry name

PSN2_HUMAN

AD4 Codon optimized cDNA(gene) Clone

AD4 Cat #

RPE0724

Tag

AD4 contains A 6x histidine tag

AD4 Formulation

Liquid

AD4 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

AD4 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant AD4 Protein

AD4 Cat #

PE0724

AD4 Source

recombinant

AD4 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

AD4 Purity

>90%, as determined by SDS-PAGE under reducing conditions

AD4 Activity

N/A

Tag

AD4 Contains A 6x histidine tag

AD4 Formulation

Liquid

AD4 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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AD4 family

Peptidase A22A family

AD4 Subcellular locations

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.

AD4 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.

AD4 Sequence

DDBJ

EMBL

GenBank

AD4 3D structure

ModBase

AD4 interaction

STRING

AD4 Proteomic

PRIDE

AD4 Genome annotation

Ensembl

GeneID

KEGG

UCSC

AD4 Organism specific

CTD

MGI

AD4 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

AD4 Gene expression

Bgee

ArrayExpress

Genevestigator

AD4 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY