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Human Sequestosome-1 (aa 1–440)

ORCA Swiss Prot#

Q13501

ORCA Protein names

Sequestosome-1 (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (EBI3-associated protein of 60 kDa) (p60) (EBIAP)

ORCA Gene names

SQSTM1 (ORCA) (OSIL)

Organism

Human

ORCA Entry name

SQSTM_HUMAN

ORCA Codon optimized cDNA(gene) Clone

ORCA Cat #

RPE0719

Tag

ORCA contains A 6x histidine tag

ORCA Formulation

Liquid

ORCA Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

ORCA Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant ORCA Protein

ORCA Cat #

PE0719

ORCA Source

recombinant

ORCA Applications

Western Blot, SDS-Page or may be used for other applications determined by user

ORCA Purity

>90%, as determined by SDS-PAGE under reducing conditions

ORCA Activity

N/A

Tag

ORCA Contains A 6x histidine tag

ORCA Formulation

Liquid

ORCA Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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ORCA family

-

ORCA Subcellular locations

Cytoplasm. Late endosome. Nucleus.

ORCA FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.

ORCA Sequence

DDBJ

EMBL

GenBank

ORCA 3D structure

ModBase

ORCA interaction

STRING

ORCA Proteomic

PRIDE

ORCA Genome annotation

Ensembl

GeneID

KEGG

UCSC

ORCA Organism specific

CTD

MGI

ORCA Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

ORCA Gene expression

Bgee

ArrayExpress

Genevestigator

ORCA Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY