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Human Mitogen-activated protein kinase 8 (aa 26–321)

JNK1 Swiss Prot#

P45983

JNK1 Protein names

Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46)

JNK1 Gene names

MAPK8 (JNK1) (PRKM8)

Organism

Human

JNK1 Entry name

MK08_HUMAN

JNK1 Codon optimized cDNA(gene) Clone

JNK1 Cat #

RPE0704

Tag

JNK1 contains A 6x histidine tag

JNK1 Formulation

Liquid

JNK1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

JNK1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant JNK1 Protein

JNK1 Cat #

PE0704

JNK1 Source

recombinant

JNK1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

JNK1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

JNK1 Activity

N/A

Tag

JNK1 Contains A 6x histidine tag

JNK1 Formulation

Liquid

JNK1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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JNK1 family

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily

JNK1 Subcellular locations

-

JNK1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).; FUNCTION: JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.

JNK1 Sequence

DDBJ

EMBL

GenBank

JNK1 3D structure

ModBase

JNK1 interaction

STRING

JNK1 Proteomic

PRIDE

JNK1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

JNK1 Organism specific

CTD

MGI

JNK1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

JNK1 Gene expression

Bgee

ArrayExpress

Genevestigator

JNK1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY