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Human Mothers against decapentaplegic homolog 3 (aa 1–425)

MADH3 Swiss Prot#

P84022

MADH3 Protein names

Mothers against decapentaplegic homolog 3 (Mad3) (hMAD-3) (Mothers against DPP homolog 3) (SMAD 3) (hSMAD3) (JV15-2)

MADH3 Gene names

SMAD3 (MADH3)

Organism

Human

MADH3 Entry name

SMAD3_HUMAN

MADH3 Codon optimized cDNA(gene) Clone

MADH3 Cat #

RPE0702

Tag

MADH3 contains A 6x histidine tag

MADH3 Formulation

Liquid

MADH3 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

MADH3 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant MADH3 Protein

MADH3 Cat #

PE0702

MADH3 Source

recombinant

MADH3 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

MADH3 Purity

>90%, as determined by SDS-PAGE under reducing conditions

MADH3 Activity

N/A

Tag

MADH3 Contains A 6x histidine tag

MADH3 Formulation

Liquid

MADH3 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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MADH3 family

Dwarfin/SMAD family

MADH3 Subcellular locations

Cytoplasm. Nucleus.

MADH3 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures (By similarity).

MADH3 Sequence

DDBJ

EMBL

GenBank

MADH3 3D structure

ModBase

MADH3 interaction

STRING

MADH3 Proteomic

PRIDE

MADH3 Genome annotation

Ensembl

GeneID

KEGG

UCSC

MADH3 Organism specific

CTD

MGI

MADH3 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

MADH3 Gene expression

Bgee

ArrayExpress

Genevestigator

MADH3 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY