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Human Glycogen synthase kinase-3 beta (aa 56–340)

GSK3B Swiss Prot#

P49841

GSK3B Protein names

Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26)

GSK3B Gene names

GSK3B

Organism

Human

GSK3B Entry name

GSK3B_HUMAN

GSK3B Codon optimized cDNA(gene) Clone

GSK3B Cat #

RPE0695

Tag

GSK3B contains A 6x histidine tag

GSK3B Formulation

Liquid

GSK3B Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

GSK3B Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant GSK3B Protein

GSK3B Cat #

PE0695

GSK3B Source

recombinant

GSK3B Applications

Western Blot, SDS-Page or may be used for other applications determined by user

GSK3B Purity

>90%, as determined by SDS-PAGE under reducing conditions

GSK3B Activity

N/A

Tag

GSK3B Contains A 6x histidine tag

GSK3B Formulation

Liquid

GSK3B Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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GSK3B family

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, GSK-3 subfamily

GSK3B Subcellular locations

Cytoplasm. Nucleus.

GSK3B FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1.

GSK3B Sequence

DDBJ

EMBL

GenBank

GSK3B 3D structure

ModBase

GSK3B interaction

STRING

GSK3B Proteomic

PRIDE

GSK3B Genome annotation

Ensembl

GeneID

KEGG

UCSC

GSK3B Organism specific

CTD

MGI

GSK3B Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

GSK3B Gene expression

Bgee

ArrayExpress

Genevestigator

GSK3B Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY