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Human NF-kappa-B essential modulator (aa 1–419)

FIP3 Swiss Prot#

Q9Y6K9

FIP3 Protein names

NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (FIP-3)

FIP3 Gene names

IKBKG (FIP3) (NEMO)

Organism

Human

FIP3 Entry name

NEMO_HUMAN

FIP3 Codon optimized cDNA(gene) Clone

FIP3 Cat #

RPE0694

Tag

FIP3 contains A 6x histidine tag

FIP3 Formulation

Liquid

FIP3 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

FIP3 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant FIP3 Protein

FIP3 Cat #

PE0694

FIP3 Source

recombinant

FIP3 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

FIP3 Purity

>90%, as determined by SDS-PAGE under reducing conditions

FIP3 Activity

N/A

Tag

FIP3 Contains A 6x histidine tag

FIP3 Formulation

Liquid

FIP3 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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FIP3 family

-

FIP3 Subcellular locations

Cytoplasm. Nucleus.

FIP3 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity (By similarity). Essential for viral activation of IRF3.

FIP3 Sequence

DDBJ

EMBL

GenBank

FIP3 3D structure

ModBase

FIP3 interaction

STRING

FIP3 Proteomic

PRIDE

FIP3 Genome annotation

Ensembl

GeneID

KEGG

UCSC

FIP3 Organism specific

CTD

MGI

FIP3 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

FIP3 Gene expression

Bgee

ArrayExpress

Genevestigator

FIP3 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY